Cephalosporin Allergies: How Cross-Reactivity with Penicillins Really Works
Cephalosporin allergies are often misunderstood. The old 10% cross-reactivity rule with penicillins is outdated. Modern evidence shows cross-reactivity is under 1% for third-gen drugs like ceftriaxone, and side chains-not the beta-lactam ring-determine risk.
